BIOCHEMICAL PARAMETERS OF RAT BLOOD SERUM AND ALVEOLAR PROCESSES IN EXPERIMENTAL MODELING OF PERIODONTITIS AGAINST THE BACKGROUND OF ALIMENTARY VITAMIN D DEFICIENCY

Abstract

In Ukraine, the health of children and adolescents deteriorates every year. Along with the deficiency of vitamin D in the development of a number of children’s diseases, including dental ones, an important role is played by the lack of nutrients in the child’s body: calcium, phosphorus, magnesium, proteins, other vitamins (C, A, group B) and minerals, the immaturity of the endocrine systems, which regulate the processes of osteogenesis, transport mechanisms and other important exchange reactions. Phosphorus-calcium exchange is affected by the presence of vitamin D, which plays an important role in metabolism, therefore it is necessary for the development of the child. At the same time, calcium activates the action of some enzymes and hormones. Phosphorus deficiency leads to an excess of calcium in the body. The development of a complex of support for the treatment of dental diseases in children against the background of vitamin D deficiency is an urgent task of modern dentistry. Purpose of the study. Experimental evaluation on rats, against the background of a model of alimentary vitamin D deficiency, changes in biochemical indicators of blood serum and alveolar process under the influence of developed therapeutic and preventive measures. Materials and methods of research. In the experimental work, the following drugs were used: Mumiyo gel (Ukraine, Ukraine), "Strong teeth" (VTP Pharmakom, Ukraine), Aquadetrim vitamin D3 (Medana Pharma S.A., Poland). The study was conducted on 36 white Wistar rats of both breeds, which were divided into 3 groups. The content of total calcium and total vitamin D was determined in blood serum. Biochemical parameters of calcium (mmol/kg) and phosphorus (mmol/kg) concentration were determined in homogenates of jaw bone tissue. The STATISTICA 6.1 computer program was used for statistical processing of the obtained results. to assess their reliability and measurement errors. Conclusions. As a result of experimental studies, we obtained data that indicate a positive effect of the treatment-prophylactic complex on the biochemical indicators of blood serum and bone tissue homogenates of rats that were on a D-deficient diet. The appointment of vitamin D3 significantly improves the determined indicators. That is, we can say that the proposed LPK can be recommended as a prophylactic tool for comprehensive prevention of periodontal diseases.