A VOLUMETRIC ASSESSMENT OF THE EFFECT OF PLATELET- ENRICHED FIBRIN AND CONCENTRATED GROWTH FACTOR ON EARLY BONE HEALING AFTER ENDODONTIC MICROSURGERY: A RANDOMIZED CONTROLLED TRIAL
DOI:
https://doi.org/10.35220/2523-420X/2026.2.10Keywords:
Endodontic microsurgery, Bone defect, Cone beam computed tomography, Platelet-rich fibrin, Concentrated growth factor.Abstract
Purpose of work. Platelet-rich plasma (PRP) is a first- generation platelet-derived material with wound healing properties. However, the preparation of PRP requires a double centrifugation process, and the addition of heterothrombin and anticoagulants can cause immune and infectious reactions. Therefore, PRP is currently rarely used. This randomized controlled clinical trial compared the effects of platelet-rich fibrin (PRF) and concentrated growth factor (CGF) on early bone healing after endodontic microsurgery. Materials and methods. Eighteen patients with isolated periapical lesions < 10 mm in the front area of maxilla were randomly assigned to three groups: control, PRF or CGF. Endodontic microsurgery was performed, and PRF or CGF membranes were placed over the bone defects in the experimental groups. The volume of the bone defect was assessed one week, three months, and six months after surgery using cone beam computed tomography and Mimics software. The results were statistically analyzed using the Kruskal-Wallis test and the post hoc Mann-Whitney U test with Bonferroni correction. Results and discissions. At three months of follow-up, the PRF and CGF groups showed significantly better bone healing compared to the control group (p > 0.05). However, no significant difference was observed between the PRF and CGF groups. At six months of follow-up, no significant difference was observed between the groups. Conclusions. According to the results of this study, the first hypothesis was adopted that PRF and CGF contribute to the early healing of bone defects after endodontic microsurgery. A second hypothesis was also adopted that there is no difference between PRF and CGF in promoting early healing of bone defects after endodontic microsurgery. Within the limitations of the study, this study clinically demonstrated that PRF and CGF have a positive effect on early bone formation and may enhance the therapeutic effectiveness of endodontic microsurgery. To further evaluate the possible benefits of PRF and CGF in endodontic microsurgery, large-scale prospective clinical studies are needed.
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