CHANGES IN THE SALIVARY ANTIOXIDANT–PROOXIDANT INDEX IN PATIENTS FOLLOWING SURGICAL TUMOUR REMOVAL AND CHEMOTHERAPY DURING THE APPLICATION OF A THERAPEUTIC AND PREVENTIVE COMPLEX
DOI:
https://doi.org/10.35220/2523-420X/2026.3.5Keywords:
head and neck cancer, oral fluid, antioxidantprooxidant index, surgical intervention, dentistry, therapeutic and preventive regimen, rehabilitationAbstract
An imbalance between antioxidant defence and lipid peroxidation contributes to altered oral homeostasis in patients with head and neck malignancies. The salivary antioxidant–prooxidant index (API) integrates catalase activity and malondialdehyde content and can be used to assess their relationship during rehabilitation. Aim of the study. To evaluate changes in salivary API in patients with head and neck cancer receiving an additional therapeutic and prophylactic complex after surgical tumour removal and chemotherapy. Materials and methods. The study included 35 individuals aged 25–55 years: 25 patients with head and neck malignancies and 10 healthy individuals. The comparison group (n = 10) received standard treatment, whereas the main group (n = 15) additionally received a therapeutic and prophylactic complex, with a repeated course after 6 months. API was calculated as the ratio of catalase activity to malondialdehyde content at baseline and after 1, 3, 6 and 12 months. Results are presented as mean ± standard error. Results. Baseline API values were 2.5 ± 0.2 arbitrary units in the comparison group and 2.8 ± 0.2 arbitrary units in the main group, compared with a reference value of 21.4 ± 1.1 arbitrary units (p < 0.001). In the main group, API increased to 5.2 ± 0.3, 8.4 ± 0.5, 11.4 ± 0.9 and 12.1 ± 1.0 arbitrary units at 1, 3, 6 and 12 months, respectively (p₁ < 0.001). At each follow-up, API was higher than in the comparison group (p₂ < 0.001) but remained below the reference level (p < 0.001). Conclusions. Administration of the therapeutic and prophylactic complex was associated with a sustained increase in salivary API, reaching 4.3 times the baseline value at 12 months. The findings indicate partial restoration of the antioxidant–prooxidant balance without reaching the reference level
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