STUDY OF TRIGLYCERIDE CONTENT IN THE ORAL FLUID OF PATIENTS WITH PERIIMPLANTITIES AGAINST THE BACKGROUND OF THE TREATMENT AND PREVENTION COMPLEX

Abstract

Peri-implantitis is one of the most common causes of complications in dental implantation, potentially leading to implant loss and reduced patient quality of life. The presence of comorbid conditions such as periodontitis and atherosclerosis can further complicate the clinical course of peri-implantitis, exacerbate inflammatory processes, and accelerate bone resorption. Investigating metabolic parameters of the oral fluid, particularly triglyceride levels, is of special importance for developing effective treatment and prevention strategies for this condition. Purpose of the study. To evaluate the impact of comprehensive therapy, including a therapeutic and preventive complex of medications, on oral fluid triglyceride levels in patients with peri-implantitis combined with periodontitis and atherosclerosis. Materials and methods. The study involved patients with peri-implantitis aged 25 to 55 years. They were divided into groups: somatically healthy individuals, patients who received only basic therapy, and patients who additionally used a treatment and prophylactic complex that included drugs with antioxidant and antiinflammatory effects, agents to restore microbiocenosis and microcirculation, and drugs with an osteotropic mechanism of action. Triglyceride levels in the oral fluid were measured using standard biochemical techniques. Statistical analysis was performed using Student’s t-test at a significance level of p<0.01. Research results. Patients with peri-implantitis and a history of periodontitis and atherosclerosis exhibited a marked (over twofold) elevation in triglyceride levels compared to healthy controls. In the comparison group, basic therapy led to a moderate decrease in triglyceride levels during the first six months, but these values returned to baseline after one year. In contrast, patients in the main group who received the therapeutic and preventive complex showed a statistically significant reduction in triglyceride concentration as early as three months into treatment, which approached the levels observed in healthy individuals by six and twelve months. Conclusions. Supplementing basic therapy with a therapeutic and preventive complex ensures a sustained reduction in oral fluid triglyceride levels among patients with peri-implantitis complicated by periodontitis and atherosclerosis. This finding underscores the necessity of a comprehensive approach targeting metabolic parameters to enhance the efficacy of treatment and prevention of periimplantitis in high-risk groups.