SYSTEMIC INFLAMMATION INDEXES AS NEW PREDICTORS OF RECURRENCE OF INFLAMMATORY DISEASES OF THE ORAL MUCOSA IN POST-COVID-19 SYNDROME
DOI:
https://doi.org/10.35220/2523-420X/2025.1.10Keywords:
COVID-19; Post Covid Syndrome; biomarker; systemic immune-inflammation index; aggregate index of systemic inflammation; systemic inflammation response indexAbstract
Purpose of the study. To assess the relationship of systemic immune inflammation by blood biomarkers – SII, AISI, SIRI and to determine the role of their levels in patients with oral manifestations of post-COVID-19 syndrome.Research methods. The study involved 83 patients (main group) who visited the dental department and had oral manifestations of post-COVID-19 syndrome with typical complaints of pain, bleeding gums, single or multiple erosions. Recurrent herpetic stomatitis was diagnosed in 51 patients, and chronic recurrent aphthous stomatitis occurred in 32 patients. The control group included 35 patients with similar clinical characteristics without a history of COVID-19. Blood samples were collected for assessment of total and differential white blood cell count using a HEMIX-5 automated hematology analyzer (SFRI, France). The degree of systemic inflammation was assessed by calculating the systemic immune inflammation index SII, the total systemic inflammation index AISI, and the systemic inflammation response index SIRI.Scientific novelty. The study found that patients with post-COVID-19 syndrome had higher white blood cell count, along with higher neutrophil and monocyte counts than the control group. However, patients with post-COVID syndrome had lower white blood cell count compared to patients without a history of COVID-19.The parameters of the hematological screening revealed a high level of SII in patients with oral manifestations of post-COVID syndrome compared to patients without a history of COVID-19. The value of the AISI in patients with prolonged COVID-19 was 1.93 times higher than in the control group. The systemic inflammation response index (SIRI) in patients with prolonged COVID-19 is 59.1 % higher than in patients without a covid history.
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