ASSESSMENT OF THE EFFECT OF THERAPEUTIC -PREVENTIVE MEASURES ON THE INDICATOR OF LIPID PEROXIDATION IN THE ORAL FLUID OF PATIENTS AFTER SURGICAL INTERVENTION TO REMOVE TUMOURS AND CHEMOTHERAPY

Abstract

Surgical excision of head-and-neck tumors combined with chemotherapy is accompanied by pronounced oxidative stress, manifested by elevated levels of lipid peroxidation (LPO) products–particularly malondialdehyde (MDH) – in saliva. Monitoring LPO is essential for preventing local and systemic complications. The purpose of the study evaluate the effect of a comprehensive therapeutic- preventive complex (TPC) on salivary MDH dynamics in patients after tumor removal and chemotherapy. Materials and methods. Thirty-five individuals aged 25–55 years were examined: 25 HNT patients (comparison group, n = 10; main group, n = 15) after surgical tumor removal followed by standard chemotherapy, and 10 apparentlyhealthy volunteers (reference group). The main group additionally received the TPC, which was readministered 6 months after treatment initiation. Salivary MDA concentration was determined biochemically at baseline and at 1, 3, 6 and 12 months. Statistical processing was performed with STATISTICA 6.1 using Student’s t-test. Research results. At baseline, MDA levels in both patient groups exceeded reference values by 2.6–2.8-fold (p < 0.001). In the comparison group, MDA decreased by only 22.2 % after 12 months (p < 0.05). Additional TPC administration produced a stepwise, statistically significant reduction in MDA: 25.6 % at 1 month, 35.9 % at 3 months, 46.1 % at 6 months, and 51.3 % at 12 months (all p < 0.001). At long-term follow-up, MDA in the main group was 26.0–34.5 % lower than in the comparison group (p < 0.001). Conclusions. The comprehensive therapeutic-preventive measures markedly suppress lipid peroxidation in the saliva of oncology patients, supporting their use in postoperative rehabilitation to reduce the risk of inflammatory and destructive complications.